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TargetMultidrug and toxin extrusion protein 2
LigandBDBM50036754
Substrate/Competitorn/a
Meas. Tech.ChEMBL_934318
IC50 36200±n/a nM
Citation Wittwer MBZur AAKhuri NKido YKosaka AZhang XMorrissey KMSali AHuang YGiacomini KM Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem 56:781-95 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Multidrug and toxin extrusion protein 2
Name:Multidrug and toxin extrusion protein 2
Synonyms:Kidney-specific H(+)/organic cation antiporter | MATE-2 | MATE2 | SLC47A2 | Solute carrier family 47 member 2 | hMATE-2
Type:PROTEIN
Mol. Mass.:65098.38
Organism:Homo sapiens (Human)
Description:ChEMBL_934314
Residue:602
Sequence:
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCG
HLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLL
LCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSV
LNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSML
MICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVF
EAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFL
ATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITL
TTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILAT
RH
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  Blast E-value cutoff:
BDBM50036754
n/a
NameBDBM50036754
Synonyms:(1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)amino]-1,3-thiazol-4-yl}methyl)thio]propanimidamide | (1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)amino]-1,3-thiazol-4-yl}methyl)thio]propanimidamide (Famotidine) | 3-(2-Guanidino-thiazol-4-ylmethylsulfanyl)-N-sulfonylamino-propionamidine | CHEMBL902 | FAMOTIDINE | Fluxid | MK-208 | N'-(aminosulfonyl)-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propanimidamide | N-sulfomoyl-3-(2-Guanidino-2H-1lambda*4*-thiazol-4-ylmethylsulfanyl)-propionamidine | Pepcid | Pepcid ac | Pepcid ac (geltab) | Pepcid rpd
TypeSmall organic molecule
Emp. Form.C8H15N7O2S3
Mol. Mass.337.445
SMILES[#7]\[#6](-[#7])=[#7]/c1nc(-[#6]-[#16]-[#6]-[#6]-[#6](=[#7])-[#7]S([#7])(=O)=O)cs1
Structure
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