| Reaction Details |
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 | Report a problem with these data |
| Target | Multidrug and toxin extrusion protein 2 |
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| Ligand | BDBM50216627 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934318 (CHEMBL2320304) |
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| IC50 | 288000±n/a nM |
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| Citation |  Wittwer, MB; Zur, AA; Khuri, N; Kido, Y; Kosaka, A; Zhang, X; Morrissey, KM; Sali, A; Huang, Y; Giacomini, KM Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem56:781-95 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Multidrug and toxin extrusion protein 2 |
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| Name: | Multidrug and toxin extrusion protein 2 |
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| Synonyms: | Kidney-specific H(+)/organic cation antiporter | MATE-2 | MATE2 | S47A2_HUMAN | SLC47A2 | Solute carrier family 47 member 2 | hMATE-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65098.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_934314 |
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| Residue: | 602 |
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| Sequence: | MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCG
HLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLL
LCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSV
LNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSML
MICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVF
EAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFL
ATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITL
TTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILAT
RH
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| BDBM50216627 |
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| n/a |
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| Name | BDBM50216627 |
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| Synonyms: | (alpha-methyl-1-adamantyl)methylamine | 1-Adamantan-1-yl-ethylamine | CHEMBL959 | RIMANTADINE | US11241393, Rimantadine | rimantadin | rimantidin |
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| Type | Small organic molecule |
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| Emp. Form. | C12H21N |
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| Mol. Mass. | 179.3018 |
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| SMILES | CC(N)C12CC3CC(CC(C3)C1)C2 |TLB:10:5:12:9.8.11,10:9:12:6.5.4,THB:4:5:8:12.3.11,4:3:6.5.10:8,1:3:6.5.10:8| |
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| Structure | 
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