Reaction Details |
| Report a problem with these data |
Target | Multidrug and toxin extrusion protein 1 |
---|
Ligand | BDBM18207 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_934320 (CHEMBL2320306) |
---|
IC50 | >500000±n/a nM |
---|
Citation | Wittwer, MB; Zur, AA; Khuri, N; Kido, Y; Kosaka, A; Zhang, X; Morrissey, KM; Sali, A; Huang, Y; Giacomini, KM Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem56:781-95 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Multidrug and toxin extrusion protein 1 |
---|
Name: | Multidrug and toxin extrusion protein 1 |
Synonyms: | MATE-1 | MATE1 | S47A1_HUMAN | SLC47A1 | Solute carrier family 47 member 1 | hMATE-1 |
Type: | PROTEIN |
Mol. Mass.: | 61928.01 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_934313 |
Residue: | 570 |
Sequence: | MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISS
VFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSA
LVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLN
QGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKL
HQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYE
LAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDH
VGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVG
LPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNV
PRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRK
QLVLRRGLLLLGVFLILLVGILVRFYVRIQ
|
|
|
BDBM18207 |
---|
n/a |
---|
Name | BDBM18207 |
Synonyms: | (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one | US10869929, Compound Dexamethasone | US11554172, Compound Dexamethasone | dexamethasone | dexamethasone (tetramethyl-rhodamine conjugated ) |
Type | Steroid |
Emp. Form. | C22H29FO5 |
Mol. Mass. | 392.4611 |
SMILES | [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C |c:28,t:24| |
Structure |
|