| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Multidrug and toxin extrusion protein 1 |
|---|
| Ligand | BDBM50366799 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_934320 (CHEMBL2320306) |
|---|
| IC50 | 9400±n/a nM |
|---|
| Citation |  Wittwer, MB; Zur, AA; Khuri, N; Kido, Y; Kosaka, A; Zhang, X; Morrissey, KM; Sali, A; Huang, Y; Giacomini, KM Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem56:781-95 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Multidrug and toxin extrusion protein 1 |
|---|
| Name: | Multidrug and toxin extrusion protein 1 |
|---|
| Synonyms: | MATE-1 | MATE1 | S47A1_HUMAN | SLC47A1 | Solute carrier family 47 member 1 | hMATE-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 61928.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_934313 |
|---|
| Residue: | 570 |
|---|
| Sequence: | MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISS
VFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSA
LVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLN
QGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKL
HQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYE
LAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDH
VGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVG
LPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNV
PRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRK
QLVLRRGLLLLGVFLILLVGILVRFYVRIQ
|
|
|
|---|
| BDBM50366799 |
|---|
| n/a |
|---|
| Name | BDBM50366799 |
|---|
| Synonyms: | TUBOCURARINE | TUBOCURARINE CHLORIDE |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H41N2O6 |
|---|
| Mol. Mass. | 609.7307 |
|---|
| SMILES | COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c23)cc7)N(C)CCc6cc5OC)c4 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
