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TargetMultidrug and toxin extrusion protein 1
LigandBDBM50131441
Substrate/Competitorn/a
Meas. Tech.ChEMBL_934320
IC50 1100±n/a nM
Citation Wittwer MBZur AAKhuri NKido YKosaka AZhang XMorrissey KMSali AHuang YGiacomini KM Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem 56:781-95 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Multidrug and toxin extrusion protein 1
Name:Multidrug and toxin extrusion protein 1
Synonyms:MATE-1 | MATE1 | SLC47A1 | Solute carrier family 47 member 1 | hMATE-1
Type:PROTEIN
Mol. Mass.:61928.01
Organism:Homo sapiens (Human)
Description:ChEMBL_934313
Residue:570
Sequence:
MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISS
VFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSA
LVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLN
QGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKL
HQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYE
LAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDH
VGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVG
LPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNV
PRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRK
QLVLRRGLLLLGVFLILLVGILVRFYVRIQ
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  Blast E-value cutoff:
BDBM50131441
n/a
NameBDBM50131441
Synonyms:9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine | CHEMBL1106 | EPINASTINE | Elestat | Flurinol | WAL 80 | WAL 801 | epinastine hydrochloride
TypeSmall organic molecule
Emp. Form.C16H15N3
Mol. Mass.249.3104
SMILESNC1=NCC2N1c1ccccc1Cc1ccccc21 |t:1|
Structure
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