Reaction Details |
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Target | Transitional endoplasmic reticulum ATPase |
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Ligand | BDBM50424916 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_934533 (CHEMBL2317274) |
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IC50 | 53±n/a nM |
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Citation | Angiolini, M; Asa, D; Avanzi, N; Badari, A; Bertrand, J; Casale, E; Cirla, A; Cozzi, L; Cauteruccio, S; Donati, D; Galvani, A; Isacchi, A; Jackson, PK; Liu, Y; Magnaghi, P; Magnuson, S; Malgesini, B; Nuvoloni, S; Orrenius, C; Polucci, P; Riceputi, L; Trucchi, B; O Brien, T; Rizzi, S; Sirtori, FR; D Alessio, R Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships. J Med Chem56:437-50 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transitional endoplasmic reticulum ATPase |
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Name: | Transitional endoplasmic reticulum ATPase |
Synonyms: | TERA_HUMAN | Transitional endoplasmic reticulum ATPase | VCP | Valosin containing protein, p97 subunit | Valosin-containing protein |
Type: | Enzyme |
Mol. Mass.: | 89300.63 |
Organism: | Homo sapiens (Human) |
Description: | P55072 |
Residue: | 806 |
Sequence: | MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID
DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT
VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI
IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF
GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL
QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI
SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV
INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN
LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG
AGPSQGSGGGTGGSVYTEDNDDDLYG
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BDBM50424916 |
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n/a |
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Name | BDBM50424916 |
Synonyms: | CHEMBL2315424 |
Type | Small organic molecule |
Emp. Form. | C28H28N4O2S |
Mol. Mass. | 484.613 |
SMILES | CC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1C |
Structure |
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