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TargetTransitional endoplasmic reticulum ATPase
LigandBDBM50424942
Substrate/Competitorn/a
Meas. Tech.ChEMBL_934533 (CHEMBL2317274)
IC50 43±n/a nM
Citation Angiolini, MAsa, DAvanzi, NBadari, ABertrand, JCasale, ECirla, ACozzi, LCauteruccio, SDonati, DGalvani, AIsacchi, AJackson, PKLiu, YMagnaghi, PMagnuson, SMalgesini, BNuvoloni, SOrrenius, CPolucci, PRiceputi, LTrucchi, BO Brien, TRizzi, SSirtori, FRD Alessio, R Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships. J Med Chem56:437-50 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transitional endoplasmic reticulum ATPase
Name:Transitional endoplasmic reticulum ATPase
Synonyms:TERA_HUMAN | Transitional endoplasmic reticulum ATPase | VCP | Valosin containing protein, p97 subunit | Valosin-containing protein
Type:Enzyme
Mol. Mass.:89300.63
Organism:Homo sapiens (Human)
Description:P55072
Residue:806
Sequence:
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID
DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT
VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI
IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF
GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL
QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI
SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV
INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN
LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG
AGPSQGSGGGTGGSVYTEDNDDDLYG
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  Blast E-value cutoff:
BDBM50424942
n/a
NameBDBM50424942
Synonyms:CHEMBL2315427
TypeSmall organic molecule
Emp. Form.C27H27N5O3S
Mol. Mass.501.6
SMILESCONC(=O)c1ccc(cc1)-c1ccc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)cc1
Structure
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