| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM50027825 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_936303 (CHEMBL2321001) |
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| Ki | <100±n/a nM |
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| Citation |  Hole, AJ; Baumli, S; Shao, H; Shi, S; Huang, S; Pepper, C; Fischer, PM; Wang, S; Endicott, JA; Noble, ME Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. J Med Chem56:660-70 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM50027825 |
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| n/a |
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| Name | BDBM50027825 |
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| Synonyms: | CHEMBL2312181 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21NO5 |
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| Mol. Mass. | 367.3951 |
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| SMILES | CN1CCC(C1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 |
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| Structure | 
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