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TargetCathepsin B
LigandBDBM50415097
Substrate/Competitorn/a
Meas. Tech.ChEMBL_936335 (CHEMBL2321267)
Ki 170000±n/a nM
Citation Sosic, IMirkovic, BArenz, KStefane, BKos, JGobec, S Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives. J Med Chem56:521-33 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin B
Name:Cathepsin B
Synonyms:APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:Enzyme
Mol. Mass.:37819.69
Organism:Homo sapiens (Human)
Description:gi_63102437
Residue:339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50415097
n/a
NameBDBM50415097
Synonyms:CHEMBL570897
TypeSmall organic molecule
Emp. Form.C14H14N2O2
Mol. Mass.242.2732
SMILES[O-][N+](=O)c1ccc(N2CCCC2)c2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: