| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Leukotriene A-4 hydrolase |
|---|
| Ligand | BDBM24220 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_936851 (CHEMBL2320733) |
|---|
| IC50 | 365±n/a nM |
|---|
| Citation |  Eccles, W; Blevitt, JM; Booker, JN; Chrovian, CC; Crawford, S; de Leon, AR; Deng, X; Fourie, AM; Grice, CA; Herman, K; Karlsson, L; Kearney, AM; Lee-Dutra, A; Liang, J; Luna, R; Pippel, D; Rao, N; Riley, JP; Santillán, A; Savall, B; Tanis, VM; Xue, X; Young, AL Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase. Bioorg Med Chem Lett23:811-5 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Leukotriene A-4 hydrolase |
|---|
| Name: | Leukotriene A-4 hydrolase |
|---|
| Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
|---|
| Type: | Hydrolase; metalloprotease |
|---|
| Mol. Mass.: | 69280.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant LTA4H. |
|---|
| Residue: | 611 |
|---|
| Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
|
|
|
|---|
| BDBM24220 |
|---|
| n/a |
|---|
| Name | BDBM24220 |
|---|
| Synonyms: | 1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}piperidin-4-yl)pyrrolidin-2-one | Benzthiazole compound, 11j |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H27N3O3S |
|---|
| Mol. Mass. | 437.554 |
|---|
| SMILES | O=C1CCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
