Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetLeukotriene A-4 hydrolase
LigandBDBM50425173
Substrate/Competitorn/a
Meas. Tech.ChEMBL_936844 (CHEMBL2320478)
IC50 330±n/a nM
Citation Eccles, WBlevitt, JMBooker, JNChrovian, CCCrawford, Sde Leon, ARDeng, XFourie, AMGrice, CAHerman, KKarlsson, LKearney, AMLee-Dutra, ALiang, JLuna, RPippel, DRao, NRiley, JPSantillán, ASavall, BTanis, VMXue, XYoung, AL Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase. Bioorg Med Chem Lett23:811-5 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukotriene A-4 hydrolase
Name:Leukotriene A-4 hydrolase
Synonyms:LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:Hydrolase; metalloprotease
Mol. Mass.:69280.41
Organism:Homo sapiens (Human)
Description:Human recombinant LTA4H.
Residue:611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50425173
n/a
NameBDBM50425173
Synonyms:CHEMBL2313558
TypeSmall organic molecule
Emp. Form.C21H20N2O2S
Mol. Mass.364.461
SMILESC(N1CCCCC1)c1cc2cc(Oc3nc4ccccc4s3)ccc2o1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: