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TargetLeukotriene A4 hydrolase
LigandBDBM50425165
Substrate/Competitorn/a
Meas. Tech.ChEMBL_936852
IC50 250±n/a nM
Citation Eccles WBlevitt JMBooker JNChrovian CCCrawford Sde Leon ARDeng XFourie AMGrice CAHerman KKarlsson LKearney AMLee-Dutra ALiang JLuna RPippel DRao NRiley JPSantillán ASavall BTanis VMXue XYoung AL Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase. Bioorg Med Chem Lett 23:811-5 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukotriene A4 hydrolase
Name:Leukotriene A4 hydrolase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:69048.58
Organism:Mus musculus
Description:ChEMBL_936852
Residue:611
Sequence:
MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDL
TIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAP
DPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGES
HPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSV
TTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAK
EEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVT
AMLVGRDLKVD
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  Blast E-value cutoff:
BDBM50425165
n/a
NameBDBM50425165
Synonyms:CHEMBL2313264
TypeSmall organic molecule
Emp. Form.C23H21N3O3S
Mol. Mass.419.496
SMILESCC(=O)N1C[C@@H]2C[C@H]1CN2Cc1coc2cc(Oc3nc4ccccc4s3)ccc12 |r|
Structure
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