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TargetLeukotriene A-4 hydrolase
LigandBDBM50425170
Substrate/Competitorn/a
Meas. Tech.ChEMBL_936852 (CHEMBL2320734)
IC50 17±n/a nM
Citation Eccles, WBlevitt, JMBooker, JNChrovian, CCCrawford, Sde Leon, ARDeng, XFourie, AMGrice, CAHerman, KKarlsson, LKearney, AMLee-Dutra, ALiang, JLuna, RPippel, DRao, NRiley, JPSantillán, ASavall, BTanis, VMXue, XYoung, AL Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase. Bioorg Med Chem Lett23:811-5 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukotriene A-4 hydrolase
Name:Leukotriene A-4 hydrolase
Synonyms:LKHA4_MOUSE | Leukotriene A4 hydrolase | Lta4h
Type:PROTEIN
Mol. Mass.:69048.58
Organism:Mus musculus
Description:ChEMBL_936852
Residue:611
Sequence:
MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDL
TIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAP
DPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGES
HPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSV
TTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAK
EEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVT
AMLVGRDLKVD
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  Blast E-value cutoff:
BDBM50425170
n/a
NameBDBM50425170
Synonyms:CHEMBL2313569
TypeSmall organic molecule
Emp. Form.C22H22N4O3S
Mol. Mass.422.5
SMILESCC(=O)NC1CCN(Cc2coc3cc(Oc4nc5ncccc5s4)ccc23)CC1
Structure
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