| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Toll-like receptor 7 |
|---|
| Ligand | BDBM50425235 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_933767 (CHEMBL2321103) |
|---|
| EC50 | 49±n/a nM |
|---|
| Citation |  Nakamura, T; Wada, H; Kurebayashi, H; McInally, T; Bonnert, R; Isobe, Y Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg Med Chem Lett23:669-72 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Toll-like receptor 7 |
|---|
| Name: | Toll-like receptor 7 |
|---|
| Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 120945.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NYK1 |
|---|
| Residue: | 1049 |
|---|
| Sequence: | MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
|
|
|
|---|
| BDBM50425235 |
|---|
| n/a |
|---|
| Name | BDBM50425235 |
|---|
| Synonyms: | CHEMBL2315167 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H27N9O |
|---|
| Mol. Mass. | 397.4774 |
|---|
| SMILES | CCCCNc1nc(N)c2[nH]c(=O)n(Cc3ccc(nc3)N3CCNCC3)c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
