| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50425522 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_936062 (CHEMBL2319304) |
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| Ki | 1.000000±n/a nM |
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| Citation |  Bornot, A; Bauer, U; Brown, A; Firth, M; Hellawell, C; Engkvist, O Systematic exploration of dual-acting modulators from a combined medicinal chemistry and biology perspective. J Med Chem56:1197-210 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50425522 |
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| n/a |
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| Name | BDBM50425522 |
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| Synonyms: | CHEMBL2313630 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30Cl2N4O3 |
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| Mol. Mass. | 517.447 |
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| SMILES | CCOC(=O)N(C1CCN(CCn2c3ccccc3n(C(C)=C)c2=O)CC1)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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