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TargetRap guanine nucleotide exchange factor 4
LigandBDBM50425554
Substrate/Competitorn/a
Meas. Tech.ChEMBL_936073 (CHEMBL2319315)
IC50 700±n/a nM
Citation Chen, HTsalkova, TChepurny, OGMei, FCHolz, GGCheng, XZhou, J Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem56:952-62 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Rap guanine nucleotide exchange factor 4
Name:Rap guanine nucleotide exchange factor 4
Synonyms:CGEF2 | EPAC 2 | EPAC2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RAPGEF4 | RPGF4_HUMAN | cAMP-GEFII | cAMP-regulated guanine nucleotide exchange factor II
Type:PROTEIN
Mol. Mass.:115526.83
Organism:Homo sapiens (Human)
Description:ChEMBL_1504794
Residue:1011
Sequence:
MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50425554
n/a
NameBDBM50425554
Synonyms:CHEMBL2313654
TypeSmall organic molecule
Emp. Form.C18H22O2S
Mol. Mass.302.431
SMILESCc1cc(C)c(c(C)c1)S(=O)(=O)c1cc(C)c(C)cc1C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: