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TargetL-lactate dehydrogenase A chain
LigandBDBM50425798
Substrate/Competitorn/a
Meas. Tech.ChEMBL_937557 (CHEMBL2320782)
IC50 325±n/a nM
Citation Kohlmann, AZech, SGLi, FZhou, TSquillace, RMCommodore, LGreenfield, MTLu, XMiller, DPHuang, WSQi, JThomas, RMWang, YZhang, SDodd, RLiu, SXu, RXu, YMiret, JJRivera, VClackson, TShakespeare, WCZhu, XDalgarno, DC Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J Med Chem56:1023-40 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
L-lactate dehydrogenase A chain
Name:L-lactate dehydrogenase A chain
Synonyms:Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:Protein
Mol. Mass.:36694.85
Organism:Homo sapiens (Human)
Description:P00338::PDB Code: 4ajp
Residue:332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50425798
n/a
NameBDBM50425798
Synonyms:CHEMBL2316886
TypeSmall organic molecule
Emp. Form.C33H31ClFN3O12S
Mol. Mass.748.129
SMILESCOc1cc(OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)COc2cc(F)cc(c2)-c2ccc(cn2)C(O)=O)c(Cl)cc1NC(=O)CSc1ccc(cn1)C(O)=O |r|
Structure
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