| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor UFO |
|---|
| Ligand | BDBM50425829 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_937897 (CHEMBL2317037) |
|---|
| IC50 | 3990±n/a nM |
|---|
| Citation |  Powell, NA; Hoffman, JK; Ciske, FL; Kaufman, MD; Kohrt, JT; Quin, J; Sheehan, DJ; Delaney, A; Baxi, SM; Catana, C; McConnell, P; Ohren, J; Perrin, LA; Edmunds, JJ Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg Med Chem Lett23:1046-50 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase receptor UFO |
|---|
| Name: | Tyrosine-protein kinase receptor UFO |
|---|
| Synonyms: | AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98316.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30530 |
|---|
| Residue: | 894 |
|---|
| Sequence: | MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
|
|
|
|---|
| BDBM50425829 |
|---|
| n/a |
|---|
| Name | BDBM50425829 |
|---|
| Synonyms: | CHEMBL2312304 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H28Cl2N6O3 |
|---|
| Mol. Mass. | 507.413 |
|---|
| SMILES | Clc1ccc(Cl)c(CNc2ncc(C(=O)NCCCN3CCOC3=O)c(NC3CCCC3)n2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
