| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C zeta type |
|---|
| Ligand | BDBM50425830 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_933462 (CHEMBL2319118) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Powell, NA; Hoffman, JK; Ciske, FL; Kaufman, MD; Kohrt, JT; Quin, J; Sheehan, DJ; Delaney, A; Baxi, SM; Catana, C; McConnell, P; Ohren, J; Perrin, LA; Edmunds, JJ Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg Med Chem Lett23:1046-50 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C zeta type |
|---|
| Name: | Protein kinase C zeta type |
|---|
| Synonyms: | KPCZ_HUMAN | PKC2 | PRKCZ | Protein Kinase C, zeta | Protein kinase C (PKC) | Protein kinase C iota type/zeta type | Protein kinase C zeta | Protein kinase C zeta (PKCζ) | Protein kinase C zeta type | Protein kinase C zeta type (PKC zeta) | Protein kinase C zeta type (PKCzeta) | nPKC-zeta |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67649.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 592 |
|---|
| Sequence: | MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
|
|
|
|---|
| BDBM50425830 |
|---|
| n/a |
|---|
| Name | BDBM50425830 |
|---|
| Synonyms: | CHEMBL2312303 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H30Cl2N6O2 |
|---|
| Mol. Mass. | 505.44 |
|---|
| SMILES | Clc1ccc(Cl)c(CNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
