Reaction Details |
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Target | Myosin light chain kinase 2, skeletal/cardiac muscle |
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Ligand | BDBM50425863 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_933533 (CHEMBL2319695) |
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IC50 | 24860±n/a nM |
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Citation | Powell, NA; Hoffman, JK; Ciske, FL; Kohrt, JT; Baxi, SM; Peng, YW; Zhong, M; Catana, C; Ohren, J; Perrin, LA; Edmunds, JJ Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg Med Chem Lett23:1051-5 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Myosin light chain kinase 2, skeletal/cardiac muscle |
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Name: | Myosin light chain kinase 2, skeletal/cardiac muscle |
Synonyms: | MYLK2 | MYLK2_HUMAN | myosin light chain kinase 2 |
Type: | PROTEIN |
Mol. Mass.: | 64687.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_586581 |
Residue: | 596 |
Sequence: | MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASE
KGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGS
QDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVP
MTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEV
GQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVC
TCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFME
YIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGH
LVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLS
PFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
NNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
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BDBM50425863 |
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n/a |
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Name | BDBM50425863 |
Synonyms: | CHEMBL2312652 |
Type | Small organic molecule |
Emp. Form. | C21H26Cl2N6O3 |
Mol. Mass. | 481.376 |
SMILES | CN1CCC(CC1)NC(=O)c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1N[C@@H]1COC[C@H]1O |r| |
Structure |
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