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TargetCalcium/calmodulin-dependent protein kinase type 1
LigandBDBM50425864
Substrate/Competitorn/a
Meas. Tech.ChEMBL_933966 (CHEMBL2317784)
IC50 19660±n/a nM
Citation Powell, NAHoffman, JKCiske, FLKohrt, JTBaxi, SMPeng, YWZhong, MCatana, COhren, JPerrin, LAEdmunds, JJ Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg Med Chem Lett23:1051-5 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calcium/calmodulin-dependent protein kinase type 1
Name:Calcium/calmodulin-dependent protein kinase type 1
Synonyms:CAMK1 | CaM kinase I | CaM kinase I alpha | CaM-KI | CaMKI-alpha | Calcium/calmodulin-dependent protein kinase type 1 | KCC1A_HUMAN
Type:PROTEIN
Mol. Mass.:41325.04
Organism:Homo sapiens (Human)
Description:ChEMBL_655701
Residue:370
Sequence:
MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE
GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR
LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG
TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP
YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK
SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT
ELSPTLPHQL
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  Blast E-value cutoff:
BDBM50425864
n/a
NameBDBM50425864
Synonyms:CHEMBL2312649
TypeSmall organic molecule
Emp. Form.C25H35Cl2N7O
Mol. Mass.520.498
SMILESCN(C)C1CCC(CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1C(=O)NC1CCN(C)CC1 |(47.36,-51.36,;48.9,-51.37,;49.67,-52.7,;49.68,-50.04,;48.92,-48.7,;49.7,-47.37,;51.23,-47.39,;52.01,-48.71,;51.22,-50.05,;52,-46.06,;51.24,-44.72,;49.7,-44.72,;48.94,-43.38,;47.4,-43.38,;46.63,-42.04,;47.41,-40.71,;46.64,-39.37,;47.41,-38.04,;45.1,-39.37,;44.33,-40.71,;42.79,-40.71,;45.1,-42.04,;49.7,-42.05,;51.24,-42.05,;52.01,-43.39,;53.55,-43.39,;54.32,-44.72,;54.32,-42.06,;55.86,-42.06,;56.62,-43.39,;58.16,-43.4,;58.94,-42.07,;60.48,-42.08,;58.17,-40.73,;56.62,-40.72,)|
Structure
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