| Reaction Details |
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 | Report a problem with these data |
| Target | Threonine--tRNA ligase 1, cytoplasmic |
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| Ligand | BDBM50426178 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_935846 (CHEMBL2317882) |
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| Ki | 5820±n/a nM |
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| Citation |  Teng, M; Hilgers, MT; Cunningham, ML; Borchardt, A; Locke, JB; Abraham, S; Haley, G; Kwan, BP; Hall, C; Hough, GW; Shaw, KJ; Finn, J Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J Med Chem56:1748-60 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Threonine--tRNA ligase 1, cytoplasmic |
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| Name: | Threonine--tRNA ligase 1, cytoplasmic |
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| Synonyms: | SYTC_HUMAN | TARS | TARS1 | Threonyl-tRNA synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83435.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_935846 |
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| Residue: | 723 |
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| Sequence: | MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEM
YNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIA
KVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIE
NGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRIL
NEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGI
SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFI
RSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMF
DHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCL
DFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFY
GPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERM
IAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNK
KIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAE
EEF
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| BDBM50426178 |
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| n/a |
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| Name | BDBM50426178 |
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| Synonyms: | CHEMBL2316960 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N4O4S |
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| Mol. Mass. | 388.441 |
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| SMILES | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1ccc2[nH]nc(C)c2c1 |r| |
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| Structure | 
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