Reaction Details |
| Report a problem with these data |
Target | Threonine--tRNA ligase 1, cytoplasmic |
---|
Ligand | BDBM50426193 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_935846 (CHEMBL2317882) |
---|
Ki | 601±n/a nM |
---|
Citation | Teng, M; Hilgers, MT; Cunningham, ML; Borchardt, A; Locke, JB; Abraham, S; Haley, G; Kwan, BP; Hall, C; Hough, GW; Shaw, KJ; Finn, J Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J Med Chem56:1748-60 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Threonine--tRNA ligase 1, cytoplasmic |
---|
Name: | Threonine--tRNA ligase 1, cytoplasmic |
Synonyms: | SYTC_HUMAN | TARS | TARS1 | Threonyl-tRNA synthetase |
Type: | PROTEIN |
Mol. Mass.: | 83435.65 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_935846 |
Residue: | 723 |
Sequence: | MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEM
YNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIA
KVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIE
NGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRIL
NEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGI
SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFI
RSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMF
DHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCL
DFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFY
GPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERM
IAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNK
KIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAE
EEF
|
|
|
BDBM50426193 |
---|
n/a |
---|
Name | BDBM50426193 |
Synonyms: | CHEMBL2316967 |
Type | Small organic molecule |
Emp. Form. | C18H23N5O4S |
Mol. Mass. | 405.471 |
SMILES | CC(C)[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)\C=C\c1cccc(c1)-c1cc(N)ncn1 |r| |
Structure |
|