| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Threonine--tRNA ligase |
|---|
| Ligand | BDBM50426183 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_935847 (CHEMBL2317883) |
|---|
| Ki | 1.8±n/a nM |
|---|
| Citation |  Teng, M; Hilgers, MT; Cunningham, ML; Borchardt, A; Locke, JB; Abraham, S; Haley, G; Kwan, BP; Hall, C; Hough, GW; Shaw, KJ; Finn, J Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J Med Chem56:1748-60 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Threonine--tRNA ligase |
|---|
| Name: | Threonine--tRNA ligase |
|---|
| Synonyms: | SYT_YERPE | ThrRS | YP_2221 | thrS | y1903 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 73649.43 |
|---|
| Organism: | Yersinia pestis |
|---|
| Description: | ChEMBL_935847 |
|---|
| Residue: | 642 |
|---|
| Sequence: | MPVITLPDGSQRHYDHAVSVLDVALDIGPGLAKACIAGRVNGELVDASDLIESDAQLAII
TAKDAEGLEILRHSCAHLLGHAIKQLWPDTKMAIGPVIDNGFYYDVDIEHTLTQEDLALL
EKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILDENISRDDRPGLYHHEEYVD
MCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWGDKKQLNAYLQRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFVRMKLKEYQYQEVKGPFMMD
RVLWEKTGHWENYAEHMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGS
CHRNEPSGALHGLMRVRGFTQDDAHVFCTEEQVRDEVNSCIKMVYDMYSTFGFEKIVVKL
STRPEKRIGSDELWTRAEDDLAAALTENGIPFDYQPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDFSLPGRLSASYIGENNDRQVPVMIHRAILGSMERFIGILTEEYAGFFPTWLAPV
QVVVMNITDSQSDYVQQVTKKLQDAGIRAKADLRNEKIGFKIREHTLRRVPYMLVCGDKE
VESGKIAVRTRRGKDLGSLDVNVVVDQLLAEIRSRSLHQLEE
|
|
|
|---|
| BDBM50426183 |
|---|
| n/a |
|---|
| Name | BDBM50426183 |
|---|
| Synonyms: | CHEMBL2311925 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H19N5O4S |
|---|
| Mol. Mass. | 377.418 |
|---|
| SMILES | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)\C=C\c1cccc(c1)-c1cc(N)ncn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
