Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Casein kinase I isoform alpha | ||
| Ligand | BDBM50191405 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_939731 (CHEMBL2329084) | ||
| IC50 | >10000±n/a nM | ||
| Citation |  Myrianthopoulos, V; Kritsanida, M; Gaboriaud-Kolar, N; Magiatis, P; Ferandin, Y; Durieu, E; Lozach, O; Cappel, D; Soundararajan, M; Filippakopoulos, P; Sherman, W; Knapp, S; Meijer, L; Mikros, E; Skaltsounis, AL Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases. ACS Med Chem Lett4:22-26 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Casein kinase I isoform alpha | |||
| Name: | Casein kinase I isoform alpha | ||
| Synonyms: | CK1 | CKI-alpha | CSNK1A1 | KC1A_PIG | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 14639.55 | ||
| Organism: | Sus scrofa | ||
| Description: | ChEMBL_939731 | ||
| Residue: | 125 | ||
| Sequence: |
| ||
| BDBM50191405 | |||
| n/a | |||
| Name | BDBM50191405 | ||
| Synonyms: | (2'Z,3'E)-7-bromoindirubin-3'-oxime | CHEMBL373834 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H10BrN3O2 | ||
| Mol. Mass. | 356.174 | ||
| SMILES | Oc1[nH]c2c(Br)cccc2c1-c1[nH]c2ccccc2c1N=O |(-1.26,-17.11,;-.79,-15.64,;.68,-15.16,;.67,-13.63,;1.81,-12.6,;3.27,-13.08,;1.49,-11.1,;.02,-10.63,;-1.11,-11.66,;-.79,-13.15,;-1.69,-14.4,;-3.23,-14.4,;-4.14,-15.67,;-5.62,-15.19,;-6.96,-15.96,;-8.3,-15.19,;-8.3,-13.64,;-6.96,-12.87,;-5.63,-13.63,;-4.15,-13.15,;-3.67,-11.68,;-4.97,-10.17,)| | ||
| Structure | 
| ||