| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform alpha |
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| Ligand | BDBM50426334 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_939731 (CHEMBL2329084) |
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| IC50 | 800±n/a nM |
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| Citation |  Myrianthopoulos, V; Kritsanida, M; Gaboriaud-Kolar, N; Magiatis, P; Ferandin, Y; Durieu, E; Lozach, O; Cappel, D; Soundararajan, M; Filippakopoulos, P; Sherman, W; Knapp, S; Meijer, L; Mikros, E; Skaltsounis, AL Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases. ACS Med Chem Lett4:22-26 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform alpha |
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| Name: | Casein kinase I isoform alpha |
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| Synonyms: | CK1 | CKI-alpha | CSNK1A1 | KC1A_PIG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 14639.55 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_939731 |
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| Residue: | 125 |
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| Sequence: | GEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED
LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFG
LAKKY
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| BDBM50426334 |
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| n/a |
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| Name | BDBM50426334 |
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| Synonyms: | CHEMBL2321948 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H10BrN3O3 |
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| Mol. Mass. | 384.184 |
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| SMILES | Brc1cccc2C(C(=O)Nc12)=C1Nc2ccc(CN=O)cc2C1=O |w:11.13| |
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| Structure | 
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