| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine--oxoglutarate transaminase 3 |
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| Ligand | BDBM50426340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_939752 (CHEMBL2329105) |
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| IC50 | 13600±n/a nM |
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| Citation |  Tuttle, JB; Anderson, M; Bechle, BM; Campbell, BM; Chang, C; Dounay, AB; Evrard, E; Fonseca, KR; Gan, X; Ghosh, S; Horner, W; James, LC; Kim, JY; McAllister, LA; Pandit, J; Parikh, VD; Rago, BJ; Salafia, MA; Strick, CA; Zawadzke, LE; Verhoest, PR Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett4:37-40 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine--oxoglutarate transaminase 3 |
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| Name: | Kynurenine--oxoglutarate transaminase 3 |
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| Synonyms: | CCBL2 | Cysteine-S-conjugate beta-lyase 2 | KAT3 | KAT3_HUMAN | KATIII | KYAT3 | Kynurenine aminotransferase III | Kynurenine--glyoxylate transaminase | Kynurenine--oxoglutarate transaminase III |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51406.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_939752 |
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| Residue: | 454 |
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| Sequence: | MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLA
ADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQK
QIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRS
KPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYD
TLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIK
HLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESV
GLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSET
KSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS
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| BDBM50426340 |
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| n/a |
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| Name | BDBM50426340 |
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| Synonyms: | CHEMBL2321943 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N2O4 |
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| Mol. Mass. | 300.3092 |
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| SMILES | COc1cc2N(O)C(=O)[C@@H](N)Cc2cc1Oc1ccccc1 |r| |
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| Structure | 
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