| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine--oxoglutarate transaminase 1 |
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| Ligand | BDBM50426341 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_939755 (CHEMBL2329108) |
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| IC50 | 2040±n/a nM |
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| Citation |  Tuttle, JB; Anderson, M; Bechle, BM; Campbell, BM; Chang, C; Dounay, AB; Evrard, E; Fonseca, KR; Gan, X; Ghosh, S; Horner, W; James, LC; Kim, JY; McAllister, LA; Pandit, J; Parikh, VD; Rago, BJ; Salafia, MA; Strick, CA; Zawadzke, LE; Verhoest, PR Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett4:37-40 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine--oxoglutarate transaminase 1 |
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| Name: | Kynurenine--oxoglutarate transaminase 1 |
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| Synonyms: | CCBL1 | Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | KAT1_HUMAN | KYAT1 | Kynurenine Aminotransferase 1/Glutamine Transaminase K | Kynurenine--oxoglutarate transaminase 1 |
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| Type: | Aminotransferase; Lyase |
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| Mol. Mass.: | 47874.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hKAT-1 was expressed and purified from Sf9 insect cells. |
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| Residue: | 422 |
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| Sequence: | MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
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| BDBM50426341 |
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| n/a |
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| Name | BDBM50426341 |
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| Synonyms: | CHEMBL2321944 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N2O3 |
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| Mol. Mass. | 270.2833 |
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| SMILES | N[C@H]1Cc2cc(Oc3ccccc3)ccc2N(O)C1=O |r| |
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| Structure | 
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