Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50426352 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_939921 (CHEMBL2327303) |
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Ki | 100±n/a nM |
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Citation | Brown, DG; Bernstein, PR; Wu, Y; Urbanek, RA; Becker, CW; Throner, SR; Dembofsky, BT; Steelman, GB; Lazor, LA; Scott, CW; Wood, MW; Wesolowski, SS; Nugiel, DA; Koch, S; Yu, J; Pivonka, DE; Li, S; Thompson, C; Zacco, A; Elmore, CS; Schroeder, P; Liu, J; Hurley, CA; Ward, S; Hunt, HJ; Williams, K; McLaughlin, J; Hoesch, V; Sydserff, S; Maier, D; Aharony, D Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. ACS Med Chem Lett4:46-51 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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BDBM50426352 |
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n/a |
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Name | BDBM50426352 |
Synonyms: | CHEMBL2321996 |
Type | Small organic molecule |
Emp. Form. | C13H15Cl2N |
Mol. Mass. | 256.171 |
SMILES | CN1CC=CC[C@@H](C1)c1ccc(Cl)c(Cl)c1 |r,c:3| |
Structure |
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