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TargetSodium-dependent noradrenaline transporter
LigandBDBM50426351
Substrate/Competitorn/a
Meas. Tech.ChEMBL_939924 (CHEMBL2327306)
Ki 17±n/a nM
Citation Brown, DGBernstein, PRWu, YUrbanek, RABecker, CWThroner, SRDembofsky, BTSteelman, GBLazor, LAScott, CWWood, MWWesolowski, SSNugiel, DAKoch, SYu, JPivonka, DELi, SThompson, CZacco, AElmore, CSSchroeder, PLiu, JHurley, CAWard, SHunt, HJWilliams, KMcLaughlin, JHoesch, VSydserff, SMaier, DAharony, D Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. ACS Med Chem Lett4:46-51 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Sodium-dependent noradrenaline transporter
Synonyms:Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (Human)
Description:P23975
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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  Blast E-value cutoff:
BDBM50426351
n/a
NameBDBM50426351
Synonyms:CHEMBL2321999
TypeSmall organic molecule
Emp. Form.C12H13Cl2N
Mol. Mass.242.144
SMILESClc1ccc(cc1Cl)[C@@H]1CNCC=CC1 |r,c:13|
Structure
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