| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM50426474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_940532 (CHEMBL2327150) |
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| IC50 | >10000±n/a nM |
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| Citation |  Liu, JJ; Higgins, B; Ju, G; Kolinsky, K; Luk, KC; Packman, K; Pizzolato, G; Ren, Y; Thakkar, K; Tovar, C; Zhang, Z; Wovkulich, PM Discovery of a highly potent, orally active mitosis/angiogenesis inhibitor r1530 for the treatment of solid tumors. ACS Med Chem Lett4:259-63 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM50426474 |
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| n/a |
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| Name | BDBM50426474 |
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| Synonyms: | CHEMBL1980391 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14ClFN4O |
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| Mol. Mass. | 356.781 |
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| SMILES | COc1cc2Nc3[nH]nc(C)c3N=C(c3ccccc3Cl)c2cc1F |t:13| |
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| Structure | 
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