| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxia-inducible factor 1-alpha |
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| Ligand | BDBM50426549 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_938618 (CHEMBL2327238) |
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| IC50 | 270±n/a nM |
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| Citation |  Minegishi, H; Fukashiro, S; Ban, HS; Nakamura, H Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Med Chem Lett4:297-301 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxia-inducible factor 1-alpha |
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| Name: | Hypoxia-inducible factor 1-alpha |
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| Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
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| Type: | Protein |
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| Mol. Mass.: | 92647.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16665 |
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| Residue: | 826 |
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| Sequence: | MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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| BDBM50426549 |
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| n/a |
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| Name | BDBM50426549 |
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| Synonyms: | CHEMBL2323955 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13N3O2 |
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| Mol. Mass. | 291.304 |
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| SMILES | C1Oc2ccc(Nc3[nH]nc-4c3Cc3ccccc-43)cc2O1 |
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| Structure | 
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