Reaction Details |
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Target | Fatty-acid amide hydrolase 1 |
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Ligand | BDBM50426684 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_939830 (CHEMBL2329423) |
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Ki | 10.0±n/a nM |
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Citation | Butini, S; Gemma, S; Brindisi, M; Maramai, S; Minetti, P; Celona, D; Napolitano, R; Borsini, F; Cabri, W; Fezza, F; Merlini, L; Dallavalle, S; Campiani, G; Maccarrone, M Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties. Bioorg Med Chem Lett23:492-5 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Fatty-acid amide hydrolase 1 |
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Name: | Fatty-acid amide hydrolase 1 |
Synonyms: | Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH1_MOUSE | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1 |
Type: | Hydrolase; single-pass membrane protein; homodimer |
Mol. Mass.: | 63227.28 |
Organism: | Mus musculus (mouse) |
Description: | Mouse brain membranes were used in the assay. |
Residue: | 579 |
Sequence: | MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQ
RFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTD
CETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAV
PFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCE
DLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTL
VPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSF
LLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALD
LNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMK
KGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS
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BDBM50426684 |
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n/a |
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Name | BDBM50426684 |
Synonyms: | CHEMBL2326494 |
Type | Small organic molecule |
Emp. Form. | C27H34N4O |
Mol. Mass. | 430.5851 |
SMILES | NC(=O)c1ccn(c1)-c1cccc(c1)N1CCN(CCCCCCc2ccccc2)CC1 |
Structure |
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