Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50426699 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_939842 (CHEMBL2329435) |
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Ki | 16±n/a nM |
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Citation | Tars, K; Vullo, D; Kazaks, A; Leitans, J; Lends, A; Grandane, A; Zalubovskis, R; Scozzafava, A; Supuran, CT Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases. J Med Chem56:293-300 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50426699 |
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n/a |
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Name | BDBM50426699 |
Synonyms: | CHEMBL2326517 |
Type | Small organic molecule |
Emp. Form. | C11H9N3O4S |
Mol. Mass. | 279.272 |
SMILES | OCc1cn(nn1)-c1ccc2OS(=O)(=O)C=Cc2c1 |c:16| |
Structure |
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