| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50426822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_938159 (CHEMBL2328241) |
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| Ki | 14600±n/a nM |
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| Citation |  Bozdag, M; Dreker, T; Henry, C; Tosco, P; Vallaro, M; Fruttero, R; Scozzafava, A; Carta, F; Supuran, CT Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors. Bioorg Med Chem Lett23:715-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50426822 |
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| n/a |
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| Name | BDBM50426822 |
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| Synonyms: | 1-(4-Hydroxyphenyl)Guanidine Hydrochloride | CHEMBL2323124 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H9N3O |
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| Mol. Mass. | 151.1659 |
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| SMILES | [#7]\[#6](-[#7])=[#7]\c1ccc(-[#8])cc1 |
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| Structure | 
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