| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidylate synthase |
|---|
| Ligand | BDBM50426855 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_938342 (CHEMBL2329016) |
|---|
| Ki | 300±n/a nM |
|---|
| Citation |  Ferrari, S; Ingrami, M; Soragni, F; Wade, RC; Costi, MP Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors. Bioorg Med Chem Lett23:663-8 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidylate synthase |
|---|
| Name: | Thymidylate synthase |
|---|
| Synonyms: | TS | TSase | TYSY_ECOLI | Thymidylate Synthase (TS) | thyA |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 30475.81 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | n/a |
|---|
| Residue: | 264 |
|---|
| Sequence: | MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK
NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS
YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF
DYRFEDFEIEGYDPHPGIKAPVAI
|
|
|
|---|
| BDBM50426855 |
|---|
| n/a |
|---|
| Name | BDBM50426855 |
|---|
| Synonyms: | CHEMBL2323403 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H13NO5S |
|---|
| Mol. Mass. | 379.386 |
|---|
| SMILES | O=C1OC(=O)c2cc(NS(=O)(=O)\C=C\c3ccccc3)cc3cccc1c23 |
|---|
| Structure | 
|
|---|
Search and Browse
