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TargetRAC-beta serine/threonine-protein kinase
LigandBDBM50427343
Substrate/Competitorn/a
Meas. Tech.ChEMBL_941088 (CHEMBL2330885)
IC50 190±n/a nM
Citation Addie, MBallard, PButtar, DCrafter, CCurrie, GDavies, BRDebreczeni, JDry, HDudley, PGreenwood, RJohnson, PDKettle, JGLane, CLamont, GLeach, ALuke, RWMorris, JOgilvie, DPage, KPass, MPearson, SRuston, L Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. J Med Chem56:2059-73 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RAC-beta serine/threonine-protein kinase
Name:RAC-beta serine/threonine-protein kinase
Synonyms:AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:Enzyme
Mol. Mass.:55766.64
Organism:Homo sapiens (Human)
Description:n/a
Residue:481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
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  Blast E-value cutoff:
BDBM50427343
n/a
NameBDBM50427343
Synonyms:CHEMBL2325985 | US10654855, Example 43 | US11236095, Example 43 | US9492453, 43
TypeSmall organic molecule
Emp. Form.C26H27ClN6O
Mol. Mass.474.985
SMILESNC1(CCN(CC1)c1ncnc2[nH]ccc12)C(=O)NC(Cc1ccccc1)c1ccc(Cl)cc1
Structure
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