| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C epsilon type |
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| Ligand | BDBM50427363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_941100 (CHEMBL2330897) |
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| Ki | 1.000000±n/a nM |
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| Citation |  Jimenez, JM; Boyall, D; Brenchley, G; Collier, PN; Davis, CJ; Fraysse, D; Keily, SB; Henderson, J; Miller, A; Pierard, F; Settimo, L; Twin, HC; Bolton, CM; Curnock, AP; Chiu, P; Tanner, AJ; Young, S Design and optimization of selective protein kinase C¿ (PKC¿) inhibitors for the treatment of autoimmune diseases. J Med Chem56:1799-810 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C epsilon type |
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| Name: | Protein kinase C epsilon type |
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| Synonyms: | KPCE_HUMAN | PKC epsilon | PKCE | PRKCE | Protein kinase C epsilon | Protein kinase C epsilon type | Protein kinase C, PKC; classical/novel | Protein kinase C, epsilon | nPKC-epsilon |
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| Type: | Enzyme |
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| Mol. Mass.: | 83680.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 737 |
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| Sequence: | MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT
NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE
PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP
TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN
MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA
KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE
NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG
KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD
RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL
DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED
AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI
NQEEFKGFSYFGEDLMP
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| BDBM50427363 |
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| n/a |
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| Name | BDBM50427363 |
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| Synonyms: | CHEMBL2326002 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24ClFN6O |
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| Mol. Mass. | 418.896 |
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| SMILES | CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1Cl |r| |
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| Structure | 
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