Reaction Details |
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Target | Protein kinase C gamma type |
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Ligand | BDBM50427363 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_941101 (CHEMBL2330898) |
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Ki | 725±n/a nM |
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Citation | Jimenez, JM; Boyall, D; Brenchley, G; Collier, PN; Davis, CJ; Fraysse, D; Keily, SB; Henderson, J; Miller, A; Pierard, F; Settimo, L; Twin, HC; Bolton, CM; Curnock, AP; Chiu, P; Tanner, AJ; Young, S Design and optimization of selective protein kinase C¿ (PKC¿) inhibitors for the treatment of autoimmune diseases. J Med Chem56:1799-810 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein kinase C gamma type |
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Name: | Protein kinase C gamma type |
Synonyms: | KPCG_HUMAN | PKC gamma | PKC-gamma | PKCG | PRKCG | Protein kinase C gamma | Protein kinase C gamma type | Protein kinase C, PKC; classical/novel | Protein kinase C, gamma |
Type: | Enzyme |
Mol. Mass.: | 78458.05 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells
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Residue: | 697 |
Sequence: | MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG
KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSL
LYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEA
RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRL
SVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQ
KFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKG
SFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL
HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD
LKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS
FGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS
GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRL
VLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM
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BDBM50427363 |
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n/a |
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Name | BDBM50427363 |
Synonyms: | CHEMBL2326002 |
Type | Small organic molecule |
Emp. Form. | C20H24ClFN6O |
Mol. Mass. | 418.896 |
SMILES | CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1Cl |r| |
Structure |
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