| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A3 |
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| Ligand | BDBM50427595 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_941721 (CHEMBL2330944) |
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| Ki | 5.3±n/a nM |
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| Citation |  Squarcialupi, L; Colotta, V; Catarzi, D; Varano, F; Filacchioni, G; Varani, K; Corciulo, C; Vincenzi, F; Borea, PA; Ghelardini, C; Di Cesare Mannelli, L; Ciancetta, A; Moro, S 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation. J Med Chem56:2256-69 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A3 |
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| Name: | Adenosine receptor A3 |
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| Synonyms: | A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36197.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P0DMS8 |
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| Residue: | 318 |
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| Sequence: | MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE
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| BDBM50427595 |
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| n/a |
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| Name | BDBM50427595 |
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| Synonyms: | CHEMBL2322927 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N6O |
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| Mol. Mass. | 330.3434 |
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| SMILES | Cc1nc(NC(=O)c2cccnc2)c2nn(cc2n1)-c1ccccc1 |
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| Structure | 
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