| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member C4 |
|---|
| Ligand | BDBM50427624 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_941820 (CHEMBL2329811) |
|---|
| IC50 | 3150±n/a nM |
|---|
| Citation |  Liedtke, AJ; Adeniji, AO; Chen, M; Byrns, MC; Jin, Y; Christianson, DW; Marnett, LJ; Penning, TM Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17ß-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J Med Chem56:2429-46 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member C4 |
|---|
| Name: | Aldo-keto reductase family 1 member C4 |
|---|
| Synonyms: | 3-alpha-HSD1 | 3-alpha-Hydroxysteroid Dehydrogenase Type 1 (AKR1C4) | 3-alpha-hydroxysteroid dehydrogenase type I | AK1C4_HUMAN | AKR1C4 | Aldo-keto reductase family 1 member C4 | Aldo-keto reductase family 1 member C4 (AK1C4) | CDR | CHDR | Chlordecone reductase | DD-4 | DD4 | Dihydrodiol dehydrogenase 4 | HAKRA |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37068.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P17516 |
|---|
| Residue: | 323 |
|---|
| Sequence: | MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
|
|
|
|---|
| BDBM50427624 |
|---|
| n/a |
|---|
| Name | BDBM50427624 |
|---|
| Synonyms: | CHEMBL2323522 | US9346803, Table 2, Compound 11: 9-(4-chlorobenzoyl)-6-methoxy-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18ClNO4 |
|---|
| Mol. Mass. | 383.825 |
|---|
| SMILES | COc1ccc2n(C(=O)c3ccc(Cl)cc3)c3CCC(Cc3c2c1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
