| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 3 |
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| Ligand | BDBM50121900 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_941842 (CHEMBL2329833) |
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| EC50 | 0.230000±n/a nM |
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| Citation |  Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R). J Med Chem56:2747-63 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 3 |
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| Name: | Melanocortin receptor 3 |
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| Synonyms: | MC3-R | MC3R_MOUSE | Mc3r |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35808.24 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1498848 |
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| Residue: | 323 |
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| Sequence: | MNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVI
LAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIF
DSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFI
IYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFKEILCGCNSMNLG
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| BDBM50121900 |
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| n/a |
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| Name | BDBM50121900 |
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| Synonyms: | Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 | CHEMBL439490 |
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| Type | Small organic molecule |
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| Emp. Form. | C78H111N21O19 |
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| Mol. Mass. | 1646.8452 |
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| SMILES | CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O |
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| Structure | 
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