| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SUV39H2 |
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| Ligand | BDBM50427772 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_941985 (CHEMBL2330205) |
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| IC50 | 22000±n/a nM |
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| Citation |  Liu, F; Li, F; Ma, A; Dobrovetsky, E; Dong, A; Gao, C; Korboukh, I; Liu, J; Smil, D; Brown, PJ; Frye, SV; Arrowsmith, CH; Schapira, M; Vedadi, M; Jin, J Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J Med Chem56:2110-24 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase SUV39H2 |
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| Name: | Histone-lysine N-methyltransferase SUV39H2 |
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| Synonyms: | H3-K9-HMTase 2 | Histone H3-K9 methyltransferase 2 | Histone-lysine N-methyltransferase SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (Suv39H2) | KMT1B | Lysine N-methyltransferase 1B | SUV39H2 | SUV92_HUMAN | Su(var)3-9 homolog 2 | Suppressor of variegation 3-9 homolog 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 46692.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H5I1 |
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| Residue: | 410 |
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| Sequence: | MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK
PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
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| BDBM50427772 |
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| n/a |
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| Name | BDBM50427772 |
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| Synonyms: | CHEMBL2325183 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N4O2S |
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| Mol. Mass. | 312.346 |
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| SMILES | O=C(NCC(=O)c1ccccc1)Nc1ccc2nnsc2c1 |
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| Structure | 
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