Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProtein arginine N-methyltransferase 3 [N508S]
LigandBDBM50427793
Substrate/Competitorn/a
Meas. Tech.ChEMBL_941988 (CHEMBL2330282)
IC50 5000±n/a nM
Citation Liu, FLi, FMa, ADobrovetsky, EDong, AGao, CKorboukh, ILiu, JSmil, DBrown, PJFrye, SVArrowsmith, CHSchapira, MVedadi, MJin, J Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J Med Chem56:2110-24 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein arginine N-methyltransferase 3 [N508S]
Name:Protein arginine N-methyltransferase 3 [N508S]
Synonyms:ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 | Protein arginine N-methyltransferase 3 (PRMT3)
Type:Protein
Mol. Mass.:59859.85
Organism:Homo sapiens (Human)
Description:O60678[N508S]
Residue:531
Sequence:
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSA
EETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEY
LKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAR
EDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRT
ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLN
KLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYP
DICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIK
HIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHW
KQTVFLLEKPFSVKAGEALKGKVTVHKSKKDPRSLTVTLTLNNSTQTYGLQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50427793
n/a
NameBDBM50427793
Synonyms:CHEMBL2325192
TypeSmall organic molecule
Emp. Form.C15H12F2N4OS
Mol. Mass.334.344
SMILESFC(F)(CNC(=O)Nc1ccc2nnsc2c1)c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: