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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein arginine N-methyltransferase 3 [N508S] | ||
| Ligand | BDBM50427797 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_941988 (CHEMBL2330282) | ||
| IC50 | 5300±n/a nM | ||
| Citation |  Liu, F; Li, F; Ma, A; Dobrovetsky, E; Dong, A; Gao, C; Korboukh, I; Liu, J; Smil, D; Brown, PJ; Frye, SV; Arrowsmith, CH; Schapira, M; Vedadi, M; Jin, J Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J Med Chem56:2110-24 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein arginine N-methyltransferase 3 [N508S] | |||
| Name: | Protein arginine N-methyltransferase 3 [N508S] | ||
| Synonyms: | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 | Protein arginine N-methyltransferase 3 (PRMT3) | ||
| Type: | Protein | ||
| Mol. Mass.: | 59859.85 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60678[N508S] | ||
| Residue: | 531 | ||
| Sequence: |
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| BDBM50427797 | |||
| n/a | |||
| Name | BDBM50427797 | ||
| Synonyms: | CHEMBL2325188 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H23N5OS | ||
| Mol. Mass. | 333.452 | ||
| SMILES | N[C@H]1CC[C@H](CCCNC(=O)Nc2ccc3nnsc3c2)CC1 |r,wU:4.4,wD:1.0,(21.99,-11.24,;20.66,-10.47,;20.66,-8.93,;19.33,-8.15,;18,-8.92,;16.67,-8.16,;15.34,-8.93,;14,-8.16,;12.67,-8.93,;11.34,-8.16,;11.33,-6.62,;10,-8.94,;8.67,-8.17,;8.66,-6.62,;7.33,-5.85,;6,-6.62,;4.53,-6.15,;3.62,-7.4,;4.53,-8.64,;6,-8.17,;7.33,-8.94,;18,-10.47,;19.33,-11.24,)| | ||
| Structure | 
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