| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase-1 |
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| Ligand | BDBM50427913 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_940979 (CHEMBL2330669) |
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| IC50 | 230±n/a nM |
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| Citation |  Van Zandt, MC; Whitehouse, DL; Golebiowski, A; Ji, MK; Zhang, M; Beckett, RP; Jagdmann, GE; Ryder, TR; Sheeler, R; Andreoli, M; Conway, B; Mahboubi, K; D'Angelo, G; Mitschler, A; Cousido-Siah, A; Ruiz, FX; Howard, EI; Podjarny, AD; Schroeter, H Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem56:2568-80 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arginase-1 |
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| Name: | Arginase-1 |
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| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34737.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_978893 |
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| Residue: | 322 |
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| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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| BDBM50427913 |
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| n/a |
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| Name | BDBM50427913 |
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| Synonyms: | CHEMBL2326093 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H27BN2O5 |
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| Mol. Mass. | 302.175 |
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| SMILES | N[C@](CCCCB(O)O)(CCN1CCC(O)CC1)C(O)=O |r| |
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| Structure | 
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