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TargetArginase-1
LigandBDBM50427900
Substrate/Competitorn/a
Meas. Tech.ChEMBL_940977 (CHEMBL2330667)
IC50 3000±n/a nM
Citation Van Zandt, MCWhitehouse, DLGolebiowski, AJi, MKZhang, MBeckett, RPJagdmann, GERyder, TRSheeler, RAndreoli, MConway, BMahboubi, KD'Angelo, GMitschler, ACousido-Siah, ARuiz, FXHoward, EIPodjarny, ADSchroeter, H Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem56:2568-80 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Arginase-1
Name:Arginase-1
Synonyms:ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:PROTEIN
Mol. Mass.:34737.53
Organism:Homo sapiens (Human)
Description:ChEMBL_978893
Residue:322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50427900
n/a
NameBDBM50427900
Synonyms:(R)-2-amino-6-borono-2-[2-(piperidin-1-yl)ethyl]hexanoic acid (ABH-PE) | CHEMBL2326089
TypeSmall organic molecule
Emp. Form.C13H27BN2O4
Mol. Mass.286.175
SMILESN[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O |r|
Structure
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