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TargetArginase-2, mitochondrial
LigandBDBM50427907
Substrate/Competitorn/a
Meas. Tech.ChEMBL_940978 (CHEMBL2330668)
IC50 550±n/a nM
Citation Van Zandt, MCWhitehouse, DLGolebiowski, AJi, MKZhang, MBeckett, RPJagdmann, GERyder, TRSheeler, RAndreoli, MConway, BMahboubi, KD'Angelo, GMitschler, ACousido-Siah, ARuiz, FXHoward, EIPodjarny, ADSchroeter, H Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem56:2568-80 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Arginase-2, mitochondrial
Name:Arginase-2, mitochondrial
Synonyms:ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:PROTEIN
Mol. Mass.:38576.93
Organism:Homo sapiens (Human)
Description:ChEMBL_978892
Residue:354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS
LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH
SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ
LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
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  Blast E-value cutoff:
BDBM50427907
n/a
NameBDBM50427907
Synonyms:CHEMBL2326099
TypeSmall organic molecule
Emp. Form.C16H25BN2O4
Mol. Mass.320.192
SMILESN[C@](CCCCB(O)O)(CCN1Cc2ccccc2C1)C(O)=O |r|
Structure
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