| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50428082 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_941648 (CHEMBL2330766) |
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| Ki | 160000±n/a nM |
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| Citation |  Liu, Y; Richardson, J; Tran, T; Al-Muhtasib, N; Xie, T; Yenugonda, VM; Sexton, HG; Rezvani, AH; Levin, ED; Sahibzada, N; Kellar, KJ; Brown, ML; Xiao, Y; Paige, M Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selectivea4ß2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. J Med Chem56:3000-11 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56502.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q05941 |
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| Residue: | 502 |
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| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50428082 |
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| n/a |
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| Name | BDBM50428082 |
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| Synonyms: | CHEMBL2323565 | US9303017, (R)-15, YL-1-171 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H22N2O |
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| Mol. Mass. | 258.3587 |
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| SMILES | CCCCC#Cc1cnc(C)c(OC[C@H]2CCN2)c1 |r| |
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| Structure | 
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