| Reaction Details |
|---|
 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
|---|
| Ligand | BDBM50428243 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_946433 (CHEMBL2339613) |
|---|
| Kd | >20000±n/a nM |
|---|
| Citation |  Bolshan, Y; Getlik, M; Kuznetsova, E; Wasney, GA; Hajian, T; Poda, G; Nguyen, KT; Wu, H; Dombrovski, L; Dong, A; Senisterra, G; Schapira, M; Arrowsmith, CH; Brown, PJ; Al-Awar, R; Vedadi, M; Smil, D Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett4:353-7 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| WD repeat-containing protein 5 |
|---|
| Name: | WD repeat-containing protein 5 |
|---|
| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36597.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P61964 |
|---|
| Residue: | 334 |
|---|
| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
|
|
|
|---|
| BDBM50428243 |
|---|
| n/a |
|---|
| Name | BDBM50428243 |
|---|
| Synonyms: | CHEMBL2337444 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19ClN4O3 |
|---|
| Mol. Mass. | 374.821 |
|---|
| SMILES | NC1CCN(CC1)c1ccc(cc1NC(=O)c1ccccc1Cl)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
